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Axin antibody (AA 330-359)

AXIN1 Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3030088
  • Target See all Axin (AXIN1) Antibodies
    Axin (AXIN1) (Axin 1 (AXIN1))
    Binding Specificity
    • 15
    • 15
    • 14
    • 8
    • 7
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 330-359
    Reactivity
    • 60
    • 56
    • 25
    • 1
    • 1
    Human
    Host
    • 86
    • 6
    • 1
    Rabbit
    Clonality
    • 87
    • 6
    Polyclonal
    Conjugate
    • 32
    • 7
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Axin antibody is un-conjugated
    Application
    • 63
    • 38
    • 38
    • 38
    • 14
    • 11
    • 9
    • 7
    • 5
    • 5
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Cross-Reactivity (Details)
    Expected species reactivity: Mouse, Rat
    Purification
    Antigen affinity purified
    Immunogen
    A portion of amino acids 330-359 from the human protein was used as the immunogen for this AXIN1 antibody.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product AXIN1 Primary Antibody
  • Application Notes
    Titration of the AXIN1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the AXIN1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    Axin (AXIN1) (Axin 1 (AXIN1))
    Alternative Name
    AXIN1 (AXIN1 Products)
    Background
    AXIN1 is a component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects, down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. [UniProt]
    UniProt
    O15169
    Pathways
    WNT Signaling, Sensory Perception of Sound, Regulation of G-Protein Coupled Receptor Protein Signaling
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