Axin antibody (AA 330-359)
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- Target See all Axin (AXIN1) Antibodies
- Axin (AXIN1) (Axin 1 (AXIN1))
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Binding Specificity
- AA 330-359
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Axin antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Cross-Reactivity (Details)
- Expected species reactivity: Mouse, Rat
- Purification
- Antigen affinity purified
- Immunogen
- A portion of amino acids 330-359 from the human protein was used as the immunogen for this AXIN1 antibody.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product AXIN1 Primary Antibody
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- Application Notes
- Titration of the AXIN1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Aliquot the AXIN1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Target
- Axin (AXIN1) (Axin 1 (AXIN1))
- Alternative Name
- AXIN1 (AXIN1 Products)
- Background
- AXIN1 is a component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects, down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. [UniProt]
- UniProt
- O15169
- Pathways
- WNT Signaling, Sensory Perception of Sound, Regulation of G-Protein Coupled Receptor Protein Signaling
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