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Caspase 3 antibody (AA 149-179)

The Rabbit Polyclonal anti-Caspase 3 antibody has been validated for WB, IHC, ELISA and FACS. It is suitable to detect Caspase 3 in samples from Human.
Catalog No. ABIN3030296

Quick Overview for Caspase 3 antibody (AA 149-179) (ABIN3030296)

Target

See all Caspase 3 (CASP3) Antibodies
Caspase 3 (CASP3)

Reactivity

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Human

Host

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Rabbit

Clonality

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Polyclonal

Conjugate

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This Caspase 3 antibody is un-conjugated

Application

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Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)
  • Binding Specificity

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    AA 149-179

    Purification

    Antigen affinity purified

    Immunogen

    A portion of amino acids 149-179 from the human protein was used as the immunogen for this Caspase-3 antibody.

    Isotype

    Ig Fraction
  • Application Notes

    Titration of the Caspase-3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50

    Restrictions

    For Research Use only
  • Format

    Liquid

    Buffer

    In 1X PBS pH 7.4 with 0.09 % sodium azide

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Aliquot the Caspase-3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target

    Caspase 3 (CASP3)

    Alternative Name

    Caspase-3

    Background

    This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

    UniProt

    P42574

    Pathways

    Apoptosis, Caspase Cascade in Apoptosis, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation
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