PARK7/DJ1 antibody (AA 1-30)

Catalog No. ABIN3032158

This Rabbit Polyclonal antibody specifically detects PARK7/DJ1 in WB, ELISA and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for PARK7/DJ1 antibody (AA 1-30) (ABIN3032158)

Target: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARK7/DJ1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-PARK7/DJ1 Antibody

Binding Specificity: AA 1-30

Cross-Reactivity (Details): Expected species reactivity: Bovine, Zebrafish

Purification: Purified

Immunogen: A portion of amino acids 1-30 from the human protein was used as the immunogen for this DJ-1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the DJ-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:10-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the DJ-1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for PARK7/DJ1

Target: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Alternative Name: DJ-1

Background: Park7/DJ-1 acts as positive regulator of androgen receptor-dependent transcription, and may function as redox-sensitive chaperone and as sensor for oxidative stress, as well as preventing aggregation of SNCA. This protein has been shown to protect neurons against oxidative stress and cell death, and to play a role in fertilization. It is detected in tau inclusions in brains from neurodegenerative disease patients, and is generally highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart, with detectable levels in placenta, brain, astrocytes, Sertoli cells, spermatogonia, spermatids and spermatozoa. Defects in Park7/DJ-1 are the cause of autosomal recessive early-onset Parkinson disease 7, a form of Parkinson disease characterized by onset before 40 years, slow progression and initial good response to levodopa.

UniProt: Q99497

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport