DNMT3B antibody (AA 389-417)

Catalog No. ABIN3030752

The Rabbit Polyclonal anti-DNMT3B antibody has been validated for WB, IHC and ELISA. It is suitable to detect DNMT3B in samples from Human.

Quick Overview for DNMT3B antibody (AA 389-417) (ABIN3030752)

Target: DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNMT3B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-DNMT3B Antibody

Binding Specificity: AA 389-417

Purification: Purified

Immunogen: A portion of amino acids 389-417 from the human protein was used as the immunogen for this Dnmt3b antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Dnmt3b antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:2000,IHC (Paraffin): 1:10-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Dnmt3b antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for DNMT3B

Target: DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))

Alternative Name: Dnmt3b

Background: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. Dnmt3b is a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF)syndrome.

UniProt: Q9UBC3