DR1 antibody (AA 83-112)

Catalog No. ABIN3029101

This Rabbit Polyclonal antibody specifically detects DR1 in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for DR1 antibody (AA 83-112) (ABIN3029101)

Target: DR1 (TATA-Binding Protein-Associated Phosphoprotein (DR1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-DR1 Antibody

Binding Specificity: AA 83-112

Cross-Reactivity (Details): Expected species reactivity: Rat, Chicken

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 83-112 from the human protein was used as the immunogen for this DR1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the DR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the DR1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for DR1

Target: DR1 (TATA-Binding Protein-Associated Phosphoprotein (DR1))

Alternative Name: DR1 (Down-Regulator of Transcription 1)

Background: This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.

UniProt: Q01658