RCAN1 antibody (AA 222-252)

Catalog No. ABIN3032453

The Rabbit Polyclonal anti-RCAN1 antibody has been validated for WB and ELISA. It is suitable to detect RCAN1 in samples from Human.

Quick Overview for RCAN1 antibody (AA 222-252) (ABIN3032453)

Target: RCAN1 (Regulator of Calcineurin 1 (RCAN1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RCAN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-RCAN1 Antibody

Binding Specificity: AA 222-252

Cross-Reactivity (Details): Expected species reactivity: Mouse, Rat, Bovine, Hamster

Purification: Purified

Immunogen: A portion of amino acids 222-252 from the human protein was used as the immunogen for this DSCR1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the DSCR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the DSCR1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for RCAN1

Target: RCAN1 (Regulator of Calcineurin 1 (RCAN1))

Alternative Name: DSCR1

Background: DSCR1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. The gene for this protein is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of DSCR1 may lead to neurofibrillary tangles such as those associated with Alzheimer disease.

UniProt: P53805

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development