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FOXA2 antibody (C-Term)

FOXA2 Reactivity: Human ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3030985
$578.58
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  • Target See all FOXA2 Antibodies
    FOXA2 (Forkhead Box A2 (FOXA2))
    Binding Specificity
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 37
    • 13
    • 12
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    Human
    Host
    • 38
    • 1
    Rabbit
    Clonality
    • 30
    • 9
    Polyclonal
    Conjugate
    • 27
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    This FOXA2 antibody is un-conjugated
    Application
    • 28
    • 11
    • 10
    • 8
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Cross-Reactivity (Details)
    Expected species reactivity: Mouse, Rat
    Purification
    Antigen affinity purified
    Immunogen
    This FOXA2 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 355-389 amino acids from the C-terminal region of human FOXA2.
    Isotype
    Ig Fraction
  • Application Notes
    Titration of the FOXA2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the FOXA2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    FOXA2 (Forkhead Box A2 (FOXA2))
    Alternative Name
    FOXA2 (FOXA2 Products)
    Synonyms
    hnf3b antibody, tcf3b antibody, hnf3beta antibody, hnf3-beta antibody, FOXA2 antibody, HNF3B antibody, TCF3B antibody, HNF-3B antibody, ax antibody, axl antibody, fkd1 antibody, ik:tdsubc_2g8 antibody, tdsubc_2g8 antibody, wu:fe05g04 antibody, xx:tdsubc_2g8 antibody, FoxA2-A antibody, FoxA2a antibody, xFD-3 antibody, xbeta-1 antibody, HNF-3b antibody, HNF3-beta antibody, HNF3beta antibody, Hnf-3b antibody, Hnf3b antibody, Tcf-3b antibody, Tcf3b antibody, HNF-3BETA antibody, forkhead box A2 antibody, forkhead box A2 L homeolog antibody, foxa2 antibody, FOXA2 antibody, foxa2.L antibody, Foxa2 antibody
    Background
    Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs, FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis, regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. [UniProt]
    UniProt
    Q9Y261
    Pathways
    Dopaminergic Neurogenesis, Regulation of Carbohydrate Metabolic Process
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