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L1CAM antibody (AA 1154-1182)

L1CAM Reactivity: Human, Mouse WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3031578
  • Target See all L1CAM Antibodies
    L1CAM (L1 Cell Adhesion Molecule (L1CAM))
    Binding Specificity
    • 16
    • 8
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1154-1182
    Reactivity
    • 103
    • 37
    • 32
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 78
    • 29
    • 2
    Rabbit
    Clonality
    • 66
    • 42
    • 1
    Polyclonal
    Conjugate
    • 57
    • 11
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This L1CAM antibody is un-conjugated
    Application
    • 53
    • 40
    • 38
    • 27
    • 24
    • 14
    • 13
    • 10
    • 7
    • 6
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
    Cross-Reactivity (Details)
    Expected species reactivity: Rat
    Purification
    Antigen affinity purified
    Immunogen
    A portion of amino acids 1154-1182 from the human protein was used as the immunogen for this L1CAM antibody.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product L1CAM Primary Antibody
  • Application Notes
    Titration of the L1CAM antibody may be required due to differences in protocols and secondary/substrate sensitivity.

    1. Cleavage by ADAM10 results in 180 and 40 kDa bands while cleavage by Plasmin results in 140 and 80 kDa bands.\. Western blot: 1:1000 (1)

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the L1CAM antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    L1CAM (L1 Cell Adhesion Molecule (L1CAM))
    Alternative Name
    L1CAM (L1CAM Products)
    Background
    L1CAM is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
    UniProt
    P32004
    Pathways
    Synaptic Membrane
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