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LIN28A antibody (N-Term)

LIN28A Reactivity: Human ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3031622
$578.58
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  • Target See all LIN28A Antibodies
    LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))
    Binding Specificity
    • 15
    • 10
    • 9
    • 8
    • 7
    • 7
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 107
    • 33
    • 24
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 85
    • 25
    Rabbit
    Clonality
    • 79
    • 31
    Polyclonal
    Conjugate
    • 50
    • 10
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    This LIN28A antibody is un-conjugated
    Application
    • 60
    • 45
    • 31
    • 29
    • 16
    • 14
    • 13
    • 13
    • 10
    • 7
    • 7
    • 3
    • 3
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Purification
    Antigen affinity purified
    Immunogen
    This LIN28A antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 22-56 amino acids from the N-terminal region of human LIN28A.
    Isotype
    Ig Fraction
  • Application Notes
    Titration of the LIN28A antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the LIN28A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))
    Alternative Name
    LIN28A (LIN28A Products)
    Synonyms
    CSDD1 antibody, LIN-28 antibody, LIN28 antibody, ZCCHC1 antibody, lin-28A antibody, AL024421 antibody, ENSMUSG00000070700 antibody, Gm10299 antibody, Lin-28 antibody, Lin28 antibody, Tex17 antibody, csdd1 antibody, lin-28 antibody, lin28 antibody, zcchc1 antibody, sb:cb650 antibody, zgc:55584 antibody, RGD1566408 antibody, lin-28 homolog A antibody, lin-28 homolog A (C. elegans) antibody, lin-28 homolog A S homeolog antibody, LIN28A antibody, Lin28a antibody, lin28a.S antibody, lin28a antibody
    Background
    Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 [removed]By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let- 7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre- let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.
    UniProt
    Q9H9Z2
    Pathways
    Stem Cell Maintenance
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