MMP14 antibody (AA 470-499)

Catalog No. ABIN3031714

This Mouse Monoclonal antibody specifically detects MMP14 in WB, ELISA and IF. It exhibits reactivity toward Human.

Quick Overview for MMP14 antibody (AA 470-499) (ABIN3031714)

Target: MMP14 (Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MMP14 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Clone: 133CT15-10-5-1

Product Details anti-MMP14 Antibody

Binding Specificity: AA 470-499

Cross-Reactivity (Details): Expected species reactivity: Mouse, Rat, Bovine, Pig, Rabbit

Purification: Purified

Immunogen: A portion of amino acids 470-499 from the human protein was used as the immunogen for this MMP14 antibody.

Isotype: IgM

Application Details

Application Notes: Titration of the MMP14 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:100-1:1000,Immunofluorescence: 1:10-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the MMP14 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for MMP14

Target: MMP14 (Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14))

Alternative Name: MMP14

Background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.

UniProt: P50281

Pathways: Autophagy