PTPN1 antibody

Catalog No. ABIN3032393

The Rabbit Polyclonal anti-PTPN1 antibody is suitable to detect PTPN1 in samples from Human and Mouse. It has been validated for WB and ELISA.

Quick Overview for PTPN1 antibody (ABIN3032393)

Target: PTPN1 (Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PTPN1 Antibody

Purpose: PTP1B Antibody

Purification: Purified

Immunogen: This PTP1B antibody was produced from rabbits immunized with a recombinant protein encoding aa 1~321 of human PTP1B.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the PTP1B antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the PTP1B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for PTPN1

Target: PTPN1 (Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))

Alternative Name: PTP1B

Background: PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.

UniProt: P18031

Pathways: TLR Signaling, Response to Growth Hormone Stimulus, ER-Nucleus Signaling, Platelet-derived growth Factor Receptor Signaling