SPR antibody (AA 231-260)

Catalog No. ABIN3029000

The Rabbit Polyclonal anti-SPR antibody is suitable to detect SPR in samples from Human and Mouse. It has been validated for WB and ELISA.

Quick Overview for SPR antibody (AA 231-260) (ABIN3029000)

Target: SPR (Sepiapterin Reductase (SPR))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPR antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SPR Antibody

Binding Specificity: AA 231-260

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 231-260 from the human protein was used as the immunogen for this SPR antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the SPR antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the SPR antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for SPR

Target: SPR (Sepiapterin Reductase (SPR))

Alternative Name: SPR

Background: SPR encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1.

UniProt: P35270

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration