NKX2-1 antibody (AA 2-1)

Catalog No. ABIN3029203

This Rabbit Polyclonal antibody specifically detects NKX2-1 in WB, FACS and ELISA. It exhibits reactivity toward Human.

Quick Overview for NKX2-1 antibody (AA 2-1) (ABIN3029203)

Target: NKX2-1 (NK2 Homeobox 1 (NKX2-1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NKX2-1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), ELISA

Product Details anti-NKX2-1 Antibody

Binding Specificity: AA 2-1

Cross-Reactivity (Details): Expected species reactivity: Mouse, Rat

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 2-1 from the human protein was used as the immunogen for this TTF1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the TTF1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Flow Cytometry: 1:10-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the TTF1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for NKX2-1

Target: NKX2-1 (NK2 Homeobox 1 (NKX2-1))

Alternative Name: NKX2.1 (TTF1)

Background: This gene encodes a protein initially identified as a thyroid-specific transcription factor. NKX2.1/TTF1 binds to thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

UniProt: P43699

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Cellular Glucan Metabolic Process, Feeding Behaviour