PER3 antibody

Catalog No. ABIN498324

The Rabbit Polyclonal anti-PER3 antibody (ABIN498324) specifically detects PER3 in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for PER3 antibody (ABIN498324)

Target: PER3 (Period Homolog 3 (PER3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PER3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PER3 Antibody

Specificity: This antibody detects endogenous levels of Per3 protein. (region surrounding Pro2)

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: Western blot 1/500-1/1000. Immunohistochemistry on Paraffin Sections: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PER3

Target: PER3 (Period Homolog 3 (PER3))

Alternative Name: PER3

Background: Biological timepieces called circadian clocks are responsible for the regulation of hormonal rhythms, sleep cycles and other behaviors. The superchiasmatic nucleus (SCN), which is located in the brain, was the first mammalian circadian clock to be discovered. A number of transcription factors appearing to be molecular components of the SCN clock have been identified. Mutations within the Clock gene increase the length of the endogenous period and cause a loss of rhythmicity of circadian oscillations. Three mammalian period proteins, designated Per1, Per2 and Per3, exhibit circadian rhythyms in the SCN.During subjective night, Per1 and Per2 RNA levels increase in response to light pulses while Per3 RNA levels show no change in response to light pulses. Tim, for timeless, interacts with Per1 as well as Per2, and Tim and Per1 negatively regulate Clock-BMAL1-induced transcription.Synonyms: Cell growth-inhibiting gene 13 protein, Circadian clock protein PERIOD 3, GIG13, Period circadian protein homolog 3, hPER3

Molecular Weight: approx. 43 kDa

Gene ID: 8863

NCBI Accession: NP_058515

UniProt: P56645