FASTK antibody

Catalog No. ABIN498486

Product Details anti-FASTK Antibody

Target: FASTK (Fas-Activated serine/threonine Kinase (FASTK))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FASTK antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects endogenous levels of FAST protein. (region surrounding Arg410)

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Purity: > 95 % by SDS-PAGE

Application Details

Application Notes: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: PBS, pH ~7.2, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for FASTK

Target: FASTK (Fas-Activated serine/threonine Kinase (FASTK))

Alternative Name: FAST Kinase (FASTK Products)

Synonyms: FASTK antibody, DKFZp469E0832 antibody, FAST antibody, 0610011K02Rik antibody, 610011K02Rik antibody, Fas activated serine/threonine kinase antibody, Fas-activated serine/threonine kinase antibody, FASTK antibody, Fastk antibody

Background: The Human homolog FAST-1 and the corresponding mouse homolog, designated FAST-2, share significant sequence homology with xFAST-1, including a conserved N-terminal forkhead domain that consists of 110 amino acid residues and is essential for binding DNA and regulating transcription in embryogenesis, in tumorigenesis and in the maintenance of differentiated cell states. FAST-1 and FAST-2 also contain a distinct C-terminal Smad interaction domain that is required for the association with various Smad proteins, including Smad2, Smad3 and Smad4. Expression of FAST-1 and FAST-2 is predominantly observed during early development, with lower levels detected in adult tissues. FAST-1 and FAST-2 mediated DNA binding is attenuated by both TFGβ and activin, indicating that these FAST proteins mediate TFGβ induced signal transduction.Synonyms: FASTK, Fas-activated serine/threonine kinase

Molecular Weight: approx. 60 kDa

Gene ID: 10922

NCBI Accession: NP_006703

UniProt: Q14296