CD3D antibody (Chain delta)

Catalog No. ABIN498559

This Rabbit Polyclonal antibody specifically detects CD3D in WB. It exhibits reactivity toward Human.

Quick Overview for CD3D antibody (Chain delta) (ABIN498559)

Target: CD3D (CD3d Molecule, delta (CD3-TCR Complex) (CD3D))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD3D antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CD3D Antibody

Binding Specificity: Chain delta

Specificity: This antibody detects endogenous levels of CD3-δ protein. (region surrounding Thr56)

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography using epitope-specific immunogen

Purity: > 95 % (by SDS-PAGE)

Application Details

Application Notes: Western blot: 1: 500 - 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for CD3D

Target: CD3D (CD3d Molecule, delta (CD3-TCR Complex) (CD3D))

Alternative Name: CD3 delta Chain

Background: The CD3 complex mediates signal transduction. Defects in CD3D are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T-B+NK+ SCID) [MIM:608971]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.Synonyms: CD3D, T-cell surface glycoprotein CD3 delta chain, T3D

Molecular Weight: approx. 24 kDa

Gene ID: 915

NCBI Accession: NP_000723

UniProt: P04234

Pathways: TCR Signaling, CXCR4-mediated Signaling Events