Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Concentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target
SLC22A6
(Solute Carrier Family 22 Member 6 (SLC22A6))
HOAT1 antibody, OAT1 antibody, PAHT antibody, ROAT1 antibody, NKT antibody, Oat1 antibody, Orctl1 antibody, mOat1 antibody, slc22a6 antibody, zgc:77073 antibody, SLC22A6 antibody, Paht antibody, Roat1 antibody, nkt antibody, oat1 antibody, oat1-B antibody, paht antibody, roat1 antibody, slc22a6-B antibody, Slc22a6 antibody, solute carrier family 22 member 6 antibody, solute carrier family 22 (organic anion transporter), member 6 antibody, solute carrier family 22 (organic anion transporter), member 6, like antibody, Solute carrier family 22 member 6 antibody, solute carrier family 22 (organic anion transporter), member 6 S homeolog antibody, SLC22A6 antibody, Slc22a6 antibody, slc22a6l antibody, s22a6 antibody, slc22a6.S antibody
Background
SOAT1 (sterol O-acyltransferase 1), also designated ACAT1, is a homotetrameric enzyme that catalyzes the formation of cholesterol esters from cholesterol and long-chain fatty acyl coenzyme A. The gene encoding human SOAT1 maps to chromosome 1 and is expressed as a protein that localizes to the endoplasmic reticulum (ER) in several tissues, including liver, kidney, adrenal glands and macrophages. SOAT1 is involved in cellular cholesterol homeostasis as well as in foam cell formation and the subsequent progression of atherosclerosis. Several SOAT inhibitors have been developed for the treatment of atherosclerosis. SOAT2 (sterol Oacyltransferase 2), also known as ACAT2 (acyl coenzyme A), participates in lipoprotein assembly, catalyzing cholesterol esterification in mammalian cells. SOAT2 is an integral membrane protein that localizes to the ER of human intestinal cells. SOAT2 deficiency contributes to severe mental retardation and hypotonus.Synonyms: Organic anion transporter 1, PAH transporter, PAHT, ROAT, Renal organic anion transporter 1, Solute carrier family 22 member 6