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ATP7A antibody
ATP7A
Reactivity: Human, Rat, Mouse
IHC (p)
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-ATP7A Antibody
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Target
See all ATP7A Antibodies
ATP7A
(ATPase, Cu++ Transporting, alpha Polypeptide (ATP7A))
Reactivity
All reactivities for ATP7A antibodies
Human, Rat, Mouse
Host
All hosts for ATP7A antibodies
Rabbit
Clonality
All clonalities for ATP7A antibodies
Polyclonal
Conjugate
All conjugates for ATP7A antibodies
This ATP7A antibody is un-conjugated
Application
All applications for ATP7A antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificity
This antibody detects endogenous levels of ATP7A protein. (region surrounding His640)
Cross-Reactivity (Details)
Species reactivity (expected):Mouse and Rat. Species reactivity (tested):Human.
Purification
Affinity chromatography
Purity
> 95 % by SDS-PAGE
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Discover our top product ATP7A Primary Antibody
Alternatives
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Application Details
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Application Notes
Immunohistochemistry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Concentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for ATP7A
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Target
ATP7A
(ATPase, Cu++ Transporting, alpha Polypeptide (ATP7A))
Alternative Name
ATP7A (ATP7A Products )
Synonyms
ATP7A antibody, cal antibody, wu:fc43e01 antibody, zgc:153422 antibody, zgc:158633 antibody, DDBDRAFT_0218568 antibody, DDBDRAFT_0235190 antibody, DDB_0218568 antibody, DDB_0235190 antibody, atpase antibody, Atp7a antibody, kal antibody, atp7a antibody, DSMAX antibody, MK antibody, MNK antibody, SMAX3 antibody, Blo antibody, DXHXS1608e antibody, I14 antibody, Mo antibody, blotchy antibody, br antibody, brindled antibody, mottled antibody, Mnk antibody, ATPase copper transporting alpha antibody, ATPase, Cu++ transporting, alpha polypeptide antibody, P-type ATPase antibody, ATP synthase subunit a antibody, copper-transporting ATPase 1 antibody, ATP7A antibody, atp7a antibody, LOC100049514 antibody, Atp7a antibody, LOC412379 antibody
Background
The copper efflux transporters ATP7A and ATP7B sequester intracellular copper into the vesicular secretory pathway for export from the cell. ATP7A functions as a transmembrane copper-translocating P-type ATPase and plays a vital role in systemic copper absorption in the gut and copper reabsorption in the kidney. Polarized epithelial cells such as Madin-Darby canine kidney cells are a physiologically relevant model for systemic copper absorption and reabsorption in vivo. Although ATP7A is not detectable in most normal tissues it is expressed in a considerable fraction of many common tumor types. Increased expression of ATP7A renders cells resistant to cisplatin and carboplatin.Synonyms: Copper pump 1, Copper-transporting ATPase 1, MC1, MNK, Menkes disease-associated protein
Gene ID
538
NCBI Accession
NP_000043
UniProt
Q04656
Pathways
Transition Metal Ion Homeostasis , Ribonucleoside Biosynthetic Process
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