C1QBP antibody

Catalog No. ABIN499052

The Rabbit Polyclonal anti-C1QBP antibody is suitable to detect C1QBP in samples from Human, Mouse and Rat. It has been validated for WB.

Quick Overview for C1QBP antibody (ABIN499052)

Target: C1QBP (Complement Component 1, Q Subcomponent Binding Protein (C1QBP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C1QBP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-C1QBP Antibody

Specificity: This antibody detects endogenous levels of C1QBP protein. (region surrounding Lys100)

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Purity: > 95 % by SDS-PAGE

Application Details

Application Notes: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for C1QBP

Target: C1QBP (Complement Component 1, Q Subcomponent Binding Protein (C1QBP))

Alternative Name: C1QBP

Background: The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system (SCS). The SCS contains over 30 glycoproteins that influence physiological mechanisms of the body in response to immune complex (the classical pathway), carbohydrate (the lectin pathway) or bacterial (alternative pathway) initiation. C1q binding protein (C1QBP), also designated gC1q-R, p32 (p33) or HABP1 (hyaluronanbinding protein 1), is known to bind the globular heads of C1q molecules and inhibit C1 activation. C1QBP has been described as a complement receptor for C1q on B cells, neutrophils and mast cells. The C1QBP protein may form homodimers. C1QBP is expressed in vascular endothelial cells and has been found to be a multifunctional protein interacting with elements of complement, coagulation and kinin systems. In addition, C1QBP is a subunit of pre-mRNA splicing factor SF2/ASF.Synonyms: Complement component 1 Q subcomponent-binding protein, GC1QBP, GC1q-R protein, GC1q-R protein, Glycoprotein gC1qBP, HABP1, Hyaluronan-binding protein 1, Mitochondrial matrix protein p32, SF2P32, p32, p33, p33

Molecular Weight: approx. 32 kDa

Gene ID: 708

NCBI Accession: NP_001203

UniProt: Q07021

Pathways: Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly