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GRAP2 antibody

GRAP2 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499081
  • Target See all GRAP2 Antibodies
    GRAP2 (GRB2-Related Adaptor Protein 2 (GRAP2))
    Reactivity
    • 56
    • 4
    • 3
    Human
    Host
    • 51
    • 6
    • 1
    • 1
    Rabbit
    Clonality
    • 54
    • 5
    Polyclonal
    Conjugate
    • 29
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GRAP2 antibody is un-conjugated
    Application
    • 52
    • 27
    • 13
    • 13
    • 7
    • 5
    • 5
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Specificity
    This antibody detects endogenous levels of GRAP2 protein. (region surrounding asn158)
    Cross-Reactivity (Details)
    Species reactivity (tested):Human.
    Purification
    Affinity chromatography using epitope-specific immunogen
    Purity
    > 95 % pure by SDS-PAGE
    Top Product
    Discover our top product GRAP2 Primary Antibody
  • Application Notes
    Western blot: 1: 500 - 1: 1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    GRAP2 (GRB2-Related Adaptor Protein 2 (GRAP2))
    Alternative Name
    GRAP2 (GRAP2 Products)
    Synonyms
    GADS antibody, GRAP-2 antibody, GRB2L antibody, GRBLG antibody, GRID antibody, GRPL antibody, GrbX antibody, Grf40 antibody, Mona antibody, P38 antibody, Gads antibody, GrpL antibody, zgc:112091 antibody, GRAP2 antibody, grap2 antibody, zgc:65942 antibody, GRB2-related adaptor protein 2 antibody, GRB2-related adaptor protein 2a antibody, GRB2-related adaptor protein 2b antibody, GRAP2 antibody, Grap2 antibody, grap2a antibody, grap2 antibody, grap2b antibody
    Background
    In general, it exists in association with catalytic domains, as in the nonreceptor protein-tyrosine kinases and phospholipase C-γ, within structural proteins, such as spectrin or myosin, and in small adapter proteins, such as Crk and GRB2. SH3 domains are often accompanied by SH2 domains of 100 amino acids that bind to tyrosine-phosphorylated regions of target proteins, frequently linking activated growth factors to putative signal transduction proteins. Deletion or mutation of SH3 domains generally activates the transforming potential of nonreceptor tyrosine kinases, suggesting that SH3 mediates negative regulation of an intrinsic transforming activity. Gads is an adapter proteins that contains both SH2 and SH3 domains. Gads binds to tyrosine-phosphorylated proteins, such as Shc, and functions to couple these proteins to downstream effectors.Synonyms: Adapter protein GRID, GADS, GRB-2-like protein, GRB2-related adapter protein 2, GRB2L, GRBLG, GRBX, GRID, Grf-40, Grf40 adapter protein, Growth factor receptor-binding protein, Hematopoietic cell-associated adapter protein GrpL, SH3-SH2-SH3 adapter Mona
    Molecular Weight
    approx. 38 kDa
    Gene ID
    9402
    NCBI Accession
    NP_004801
    UniProt
    O75791
    Pathways
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway
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