AIFM3 antibody (Center)

Catalog No. ABIN499243

Product Details anti-AIFM3 Antibody

Target: AIFM3 (Apoptosis-Inducing Factor, Mitochondrion-Associated, 3 (AIFM3))

Binding Specificity: Center

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AIFM3 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to AIFM3.

Purification: Affinity chromatography purified via peptide column

Immunogen: AIFM3 antibody was raised against a 16 amino acid peptide from near the center of human AIFM3.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: AIFM3 antibody can be used for the detection of AIFM3 at 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for AIFM3

Target: AIFM3 (Apoptosis-Inducing Factor, Mitochondrion-Associated, 3 (AIFM3))

Abstract: AIFM3 Products

Synonyms: nfrl-A antibody, MGC84340 antibody, AIFM3 antibody, LOC100150876 antibody, 2810401C16Rik antibody, AI840249 antibody, Aifl antibody, RGD1306028 antibody, AIFL antibody, apoptosis inducing factor, mitochondria associated 3 L homeolog antibody, apoptosis inducing factor, mitochondria associated 3 antibody, apoptosis-inducing factor, mitochondrion-associated 3 antibody, aifm3.L antibody, AIFM3 antibody, aifm3 antibody, Aifm3 antibody

Background: Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. Recently a protein similar to the apoptosis-inducing factor (AIF) was cloned and designated AIFL (also known as AIFM3). AIFM3 is expressed ubiquitously and is predominantly localized to the inner membranes of mitochondria. Unlike AIF, AIFM3 does not translocate to the nucleus upon induction of apoptosis. However, overexpression of AIFM3, like AIF, induced cytochrome c release from the mitochondria, cleavage of caspase 3, and ultimately apoptosis, indicating AIFM3 induces apoptosis through caspase activation. Multiple isoforms of AIFM3 are known to exist.Synonyms: AIFL, Apoptosis-inducing factor 3

Gene ID: 150209

UniProt: Q96NN9

Pathways: Positive Regulation of Endopeptidase Activity, Cell RedoxHomeostasis