ARTS antibody

Catalog No. ABIN499339

This Rabbit Polyclonal antibody specifically detects ARTS in WB, IHC (p) and EIA. It exhibits reactivity toward Human.

Quick Overview for ARTS antibody (ABIN499339)

Target: ARTS

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details

Specificity: ARTS antibody was raised against a synthetic peptide corresponding to amino acids near the amino terminus of human ARTS.

Purification: Affinity chromatography purified via peptide column

Immunogen: Human ARTS Peptide

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: ARTS antibody can be used for detection of ARTS at 0.5 to 2 μg/mL. Humanlung, kidney and spleen tissue lysates can be used as a positive control and a band at 32 kDa can be detected. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details

Target: ARTS

Background: Apoptosis is related to many diseases and development. Mitochondrial proteins, such as cytochrome c, Apaf-1, and AIF play important role in apoptosis. A novel mitochondrial septin-like protein was identified recently and designated ARTS for apoptosis related protein in TGF-b signaling pathway (1). ARTS that is encoded by the human septin H5/PNUTL2/CDCrel2b gene (1-4) is located to mitochondria and translocates to the nucleus when apoptosis occurs. ARTS is expressed in many tissues. It enhances cell death induced by TGF-b and, to a lesser extent, by other apoptotic agents, such as TNF-a and Fas ligand.

Gene ID: 5414

UniProt: Q9H315