AVEN antibody (N-Term)

Catalog No. ABIN499369

This Rabbit Polyclonal antibody specifically detects AVEN in WB, IHC (p) and EIA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for AVEN antibody (N-Term) (ABIN499369)

Target: AVEN (Apoptosis, Caspase Activation Inhibitor (AVEN))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AVEN antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-AVEN Antibody

Binding Specificity: N-Term

Specificity: This antibody reacts to AVEN.

Purification: Affinity chromatography purified via peptide column

Immunogen: Aven antibody was raised against a 18 amino acid peptide from near the amino terminus of human Aven.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: Aven antibody can be used for detection of Aven at 0.5 to 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for AVEN

Target: AVEN (Apoptosis, Caspase Activation Inhibitor (AVEN))

Alternative Name: AVEN

Background: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients. Despite its predicted molecular weight, Aven often migrates at 55 kDa in SDS-PAGE.Synonyms: Cell death regulator Aven, PDCD12, Programmed cell death 12

Gene ID: 57099

NCBI Accession: NP_065104

UniProt: Q9NQS1