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BCL2L1 antibody

This Rabbit Polyclonal antibody specifically detects BCL2L1 in WB and EIA. It exhibits reactivity toward Human.
Catalog No. ABIN499435

Quick Overview for BCL2L1 antibody (ABIN499435)

Target

See all BCL2L1 Antibodies
BCL2L1 (BCL2-Like 1 (BCL2L1))

Reactivity

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Human

Host

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Rabbit

Clonality

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Polyclonal

Conjugate

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This BCL2L1 antibody is un-conjugated

Application

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Western Blotting (WB), Enzyme Immunoassay (EIA)
  • Specificity

    Bcl-xL antibody was raised against a peptide corresponding to 14 amino acids near the carboxy-terminus of human Bcl-xL.

    Purification

    Ion exchange chromatography

    Immunogen

    Murine Bcl-xL Peptide

    Isotype

    IgG
  • Application Notes

    ELISA. Western Blot.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    Restrictions

    For Research Use only
  • Concentration

    1,0 mg/mL

    Buffer

    PBS containing 0.02 % sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C

    Storage Comment

    Store the antibody undiluted at 2-8 °C.
  • Target

    BCL2L1 (BCL2-Like 1 (BCL2L1))

    Alternative Name

    Bcl-2-Like 1

    Background

    Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). Bcl-xL is a member of the Bcl-2 family of proteins that are critical regulators of apoptosis (reviewed in 2 and 3). These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-xL is an anti-apoptotic mitochondrial protein related to Bcl-w and the major transcript of the bcl-x gene (4). Its high expression in tumors is correlated with advanced disease and poor prognosis (5). Bcl-xL expression level increases in response to several stimuli such as ionizing radiation and treatment with chemotherapeutic agents (6,7).Synonyms: BCL2L, BCL2L1, BCLX, Bcl-2-like protein 1, Bcl-x, Bcl2-L-1, bcl-xL, bcl-xS

    Gene ID

    598

    UniProt

    Q07817

    Pathways

    Apoptosis, Negative Regulation of intrinsic apoptotic Signaling
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