BICD2 antibody (C-Term)

Catalog No. ABIN499457

The Rabbit Polyclonal anti-BICD2 antibody has been validated for WB and EIA. It is suitable to detect BICD2 in samples from Human, Mouse and Rat.

Quick Overview for BICD2 antibody (C-Term) (ABIN499457)

Target: BICD2 (Bicaudal D Homolog 2 (BICD2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BICD2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-BICD2 Antibody

Binding Specificity: C-Term

Specificity: This antibody reacts to BICD2. It will not cross-react with BICD1.

Purification: Affinity chromatography purified via peptide column

Immunogen: BICD2 antibody was raised against a 13 amino acid peptide from near the carboxy terminus of human BICD2.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: BICD2 antibody can be used for detection of BICD2 at 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for BICD2

Target: BICD2 (Bicaudal D Homolog 2 (BICD2))

Alternative Name: BICD2

Background: BICD2 is the second human homolog discovered to the Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. Similar to the highly homologous protein BICD1, BICD2 can bind to dynein-dynactin complex, primarily through the dynamitin subunit of dynactin. The C-terminus of BICD2 targets the protein to the Golgi complex while the N-terminal domain of BICD2 co-immunoprecipitates with cytoplasmic dynein, suggesting BICD2 plays a role in the dynein-dynactin interaction on the surface of membranous organelles. Mice engineered to overexpress the BICD2 amino terminal domain in neurons developed amyotrophic lateral sclerosis (ALS)-like features such as Golgi fragmentation, neurofilament swelling in proximal axons, etc., suggesting that impaired dynein/dynactin function may explain some of the pathological features observed in ALS patients.Synonyms: Bic-D2, KIAA0699, Protein bicaudal D homolog 2

Gene ID: 23299

UniProt: Q8TD16

Pathways: Maintenance of Protein Location