BRE antibody (N-Term)

Catalog No. ABIN499497

This anti-BRE antibody is a Rabbit Polyclonal antibody detecting BRE in WB, IHC (p) and EIA. Suitable for Human, Mouse and Rat.

Quick Overview for BRE antibody (N-Term) (ABIN499497)

Target: BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BRE antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-BRE Antibody

Binding Specificity: N-Term

Specificity: This antibody reacts to BRCC45.

Purification: Affinity chromatography purified via peptide column

Immunogen: BRCC45 antibody was raised against a 18 amino acid peptide from near the amino terminus of human BRCC45.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: BRCC45 antibody can be used for detection of BRCC45 at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for BRE

Target: BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))

Alternative Name: BRE / BRCC45

Background: BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs. Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36. This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage. BRCC45 has also been suggested to function as a death receptor-associated anti-apoptotic protein by inhibiting the BID-induced activation of the mitochondrial apoptotic pathway. Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, suggesting that BRCC45 may promote tumorigenesis when overexpressed. At least three isoforms of BRCC45 are known to exist.Synonyms: BRCA1-A complex subunit BRE, BRCA1/BRCA2-containing complex subunit 45, BRCC45, BRE, Brain and reproductive organ-expressed protein

Gene ID: 9577

NCBI Accession: NP_004890

UniProt: Q9NXR7

Pathways: Positive Regulation of Response to DNA Damage Stimulus