CCDC98 antibody (N-Term)

Catalog No. ABIN499595

The Rabbit Polyclonal anti-CCDC98 antibody is suitable to detect CCDC98 in samples from Human and Mouse. It has been validated for WB, IHC (p) and EIA.

Quick Overview for CCDC98 antibody (N-Term) (ABIN499595)

Target: CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCDC98 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-CCDC98 Antibody

Binding Specificity: N-Term

Specificity: This antibody reacts to CCDC98.

Purification: Affinity chromatography purified via peptide column

Immunogen: CCDC98 antibody was raised against a 15 amino acid peptide from near the amino terminus of human CCDC98.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: CCDC98 antibody can be used for detection of CCDC98 at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for CCDC98

Target: CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))

Alternative Name: CCDC98

Background: CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.Synonyms: ABRA1, Abraxas, BRCA1-A complex subunit Abraxas, Coiled-coil domain-containing protein 98, Protein FAM175A

Gene ID: 84142

NCBI Accession: NP_620775

UniProt: Q6UWZ7

Pathways: DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus