CRMP1 antibody (C-Term)

Catalog No. ABIN499650

This anti-CRMP1 antibody is a Rabbit Polyclonal antibody detecting CRMP1 in WB, IHC (p) and EIA. Suitable for Human, Mouse and Rat.

Quick Overview for CRMP1 antibody (C-Term) (ABIN499650)

Target: CRMP1 (Collapsin Response Mediator Protein 1 (CRMP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRMP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-CRMP1 Antibody

Binding Specificity: C-Term

Specificity: CRMP1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human CRMP1.

Purification: Affinity chromatography purified via peptide column

Immunogen: Virus CRMP1 / Collapsin response mediator protein 1 / DRP-1 / dihydropyropyrimidinase- related protein 1 (C-Terminus) Peptide

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: CRMP1 antibody can be used for the detection of CRMP1 at 0.5 - 1 μg/mL.3T3cell lysate can be used as positive control. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for CRMP1

Target: CRMP1 (Collapsin Response Mediator Protein 1 (CRMP1))

Alternative Name: CRMP1 / DPYSL1

Background: Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis (1). Their continued expression in areas of high synaptic remodeling such as the cerebellum, hippocampus, and the olfactory system suggests that these proteins may also be involved in adult brain plasticity (2). CRMP-1 was initially identified as a dihydro-pyrimidinase expressed exclusively in brain (3), later studies have shown that it is involved with neurotrophin (NT) 3-induced neurite formation and outgrowth (4). CRMP-1 localization switches from axonal to somatodendritic when neurons reach functional maturity, suggesting that it is involved in early neuronal differentiation as well as in later processes related to the survival or death of the newly generated neurons (5).Synonyms: Collapsin response mediator protein 1, DRP-1, Dihydropyrimidinase-related protein 1, ULIP3, Unc-33-like phosphoprotein 3

Gene ID: 1400

UniProt: Q14194