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ANKLE2 antibody (AbBy Fluor® 750)

This Rabbit Polyclonal antibody specifically detects ANKLE2 in WB and IF (p). It exhibits reactivity toward Human, Mouse and Rat.
Catalog No. ABIN4996518

Quick Overview for ANKLE2 antibody (AbBy Fluor® 750) (ABIN4996518)

Target

ANKLE2 (Ankyrin Repeat and LEM Domain Containing 2 (ANKLE2))

Reactivity

  • 26
  • 18
  • 18
  • 1
Human, Mouse, Rat

Host

  • 23
  • 3
Rabbit

Clonality

  • 26
Polyclonal

Conjugate

  • 13
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This ANKLE2 antibody is conjugated to AbBy Fluor® 750

Application

  • 26
  • 12
  • 5
  • 4
  • 4
  • 2
  • 1
Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Cross-Reactivity

    Human, Mouse, Rat

    Purification

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human ANKLE2

    Isotype

    IgG
  • Application Notes

    IF(IHC-P) 1:50-200

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Expiry Date

    12 months
  • Target

    ANKLE2 (Ankyrin Repeat and LEM Domain Containing 2 (ANKLE2))

    Alternative Name

    ANKLE2

    Background

    Synonyms: ANKL2_HUMAN, ANKLE 2, ANKLE2, ankyrin repeat and LEM domain containing 2, Ankyrin repeat and LEM domain-containing protein 2, LEM domain containing 7, LEMD 7, LEMD7.

    Background: Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes lead to severe genetic diseases such as fatal cardiac arrhythmias and hereditary spherocytosis. ANKLE2 (ankyrin repeat and LEM domain containing 2), also known as LEMD7, is a 938 amino acid single-pass membrane protein containing an ANK repeat and a LEM domain. Exsiting as two isoforms produced by alternative splicing events, the gene encoding ANKLE2 maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5 % of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and trisomy 12p, which causes facial developmental defects and seizure disorders.

    Gene ID

    23141

    UniProt

    Q86XL3
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