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ANKLE2 antibody

ANKLE2 Reactivity: Human, Mouse, Rat WB, IF (p), IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1387145
  • Target See all ANKLE2 products
    ANKLE2 (Ankyrin Repeat and LEM Domain Containing 2 (ANKLE2))
    Reactivity
    • 26
    • 18
    • 18
    • 1
    Human, Mouse, Rat
    Host
    • 23
    • 3
    Rabbit
    Clonality
    • 26
    Polyclonal
    Conjugate
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ANKLE2 antibody is un-conjugated
    Application
    • 26
    • 12
    • 4
    • 4
    • 4
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human ANKLE2
    Isotype
    IgG
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    ANKLE2 (Ankyrin Repeat and LEM Domain Containing 2 (ANKLE2))
    Alternative Name
    ANKLE2 (ANKLE2 Products)
    Synonyms
    KIAA0692 antibody, LEMD7 antibody, Lem4 antibody, 1110001J12Rik antibody, AI661024 antibody, D5Ertd585e antibody, RGD1310191 antibody, ankyrin repeat and LEM domain containing 2 antibody, ANKLE2 antibody, Ankle2 antibody
    Background

    Synonyms: ANKL2_HUMAN, ANKLE 2, ANKLE2, ankyrin repeat and LEM domain containing 2, Ankyrin repeat and LEM domain-containing protein 2, LEM domain containing 7, LEMD 7, LEMD7.

    Background: Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes lead to severe genetic diseases such as fatal cardiac arrhythmias and hereditary spherocytosis. ANKLE2 (ankyrin repeat and LEM domain containing 2), also known as LEMD7, is a 938 amino acid single-pass membrane protein containing an ANK repeat and a LEM domain. Exsiting as two isoforms produced by alternative splicing events, the gene encoding ANKLE2 maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5 % of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and trisomy 12p, which causes facial developmental defects and seizure disorders.

    Gene ID
    23141
    UniProt
    Q86XL3
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