C1QTNF2 antibody

Catalog No. ABIN499665

This anti-C1QTNF2 antibody is a Rabbit Polyclonal antibody detecting C1QTNF2 in WB, IF and EIA. Suitable for Human, Mouse and Rat.

Quick Overview for C1QTNF2 antibody (ABIN499665)

Target: C1QTNF2 (C1q and Tumor Necrosis Factor Related Protein 2 (C1QTNF2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C1QTNF2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-C1QTNF2 Antibody

Specificity: CTRP2 antibody was raised against recombinant human CTRP2.

Purification: Affinity Purified

Immunogen: Recombinant mouse CTRP2

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: CTRP2 antibody can be used for the detection of CTRP2 at 1 μg/mL. Caco-2cell lysate can be used as positive control. These proteins are often highly modifiedpost-translationally and migrate in SDS-PAGE at positions other than their predicted size. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for C1QTNF2

Target: C1QTNF2 (C1q and Tumor Necrosis Factor Related Protein 2 (C1QTNF2))

Alternative Name: C1QTNF2

Background: Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines (reviewed in 1). One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-related proteins (CTRPs) 1-7 (2). Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are are expressed in a wide variety of tissues (3). These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene (4). Of the CTRPs, CTRP2 is most similar structurally and functionally to adiponectin. Recombinant CTRP2 rapidly activated AMPK and MAPK in cultured C2C12 cells, leading to increased glycogen accumulation and fatty acid oxidation (3).Synonyms: CTRP2, Complement C1q tumor necrosis factor-related protein 2

Gene ID: 114898

NCBI Accession: NP_114114

UniProt: Q9BXJ5