Emerin antibody (N-Term)

Catalog No. ABIN499790

The Rabbit Polyclonal anti-Emerin antibody is suitable to detect Emerin in samples from Human, Mouse and Rat. It has been validated for WB, IHC (p) and EIA.

Quick Overview for Emerin antibody (N-Term) (ABIN499790)

Target: Emerin (EMD)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Emerin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-Emerin Antibody

Binding Specificity: N-Term

Specificity: This antibody reacts to Emerin.

Purification: Affinity chromatography purified via peptide column

Immunogen: Emerin antibody was raised against a 19 amino acid peptide from near the amino terminus of human Emerin.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for Emerin

Target: Emerin (EMD)

Alternative Name: Emerin

Background: Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family that includes proteins such as LAP2 and MAN1. Each family member, including Emerin, has an ~40 amino acid LEM-domains that binds barrier-to-autointegration (BANF1), a conserved chromatin protein that also serves as a host cell component of retroviral integration complexes, including that of HIV. Emerin is anchored at the inner membrane of the nuclear envelope where it binds to nuclear intermediate filaments that are formed by lamin proteins. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene.Synonyms: EDMD, EMD, STA

Gene ID: 2010

NCBI Accession: NP_000108

UniProt: P50402