FBLN3 antibody (C-Term)

Catalog No. ABIN499838

The Rabbit Polyclonal anti-FBLN3 antibody is suitable to detect FBLN3 in samples from Human, Rat and Mouse. It has been validated for WB, IF and EIA.

Quick Overview for FBLN3 antibody (C-Term) (ABIN499838)

Target: FBLN3 (Fibulin 3 (FBLN3))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBLN3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-FBLN3 Antibody

Binding Specificity: C-Term

Specificity: This antibody reacts to Fibulin 3.

Purification: Affinity chromatography purified via peptide column

Immunogen: Fibulin 3 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human Fibulin 3.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 0.5 - 1 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for FBLN3

Target: FBLN3 (Fibulin 3 (FBLN3))

Alternative Name: Fibulin-3

Background: Fibulin 3, also known as epidermal growth factor (EGF)-containing fibulin-like extracellular matrix protein 1 (EFEMP1), is a member of the fibulin family of extracellular glycoproteins, a group of proteins that are widely distributed and frequently associated with vascular and elastic tissues. The fibulin proteins typically contain a tandem array of EGF-like repeats and a fibulin-type COOH-terminal module. Aberrant accumulation of Fibulin 3 in the endoplasmic reticulum of retinal pigment epithelial cells has been shown to be associated with inherited forms of macular degeneration, but the loss of Fibulin 3 expression does not lead to macular degeneration but rather the appearance of hernias due to a reduction of elastic fibers of fascial connective tissue. Recent experiments have shown that expression of Fibulin 3 promotes tumor growth and may thus be a therapeutic target. At least three isoforms of Fibulin 3 are known to exist. This antibody is predicted to not cross-react with other Fibulin proteins.Synonyms: DHRD, DRAD, EFEMP1, EGF-containing fibulin-like extracellular matrix protein 1, Extracellular protein S1-5, FBLN3, FBNL, Fibrillin-like protein, Fibulin 3, MLVT, MTLV, S1-5

Gene ID: 2202

NCBI Accession: NP_004096

UniProt: Q12805

Pathways: EGFR Signaling Pathway