C4d-A (AA 1001-1100) antibody (AbBy Fluor® 750)

Catalog No. ABIN4998488

The AbBy Fluor® 750-conjugated Rabbit Polyclonal anti-C4d-A antibody (ABIN4998488) specifically detects C4d-A in WB, IF (cc) and IF (p). The antibody is reactive with Human and Mouse samples.

Quick Overview for C4d-A (AA 1001-1100) antibody (AbBy Fluor® 750) (ABIN4998488)

Target: C4d-A

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: AbBy Fluor® 750

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details

Binding Specificity: AA 1001-1100

Cross-Reactivity: Human, Mouse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human C4d-A

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: C4d-A

Background:

Synonyms: C4d-A, complement C4-A proprotein, Acidic complement C4, Basic complement C4, CH, Chido blood group, Complement component 4A, Complement component 4B, RG, Rodgers blood group, CO4A_HUMAN, CO4B_HUMAN, C4A, C4, C4A2, C4A3, C4A4, C4A6, C4AD, C4S, CO4, CPAMD2, RG.

Background: This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].

Gene ID: 720

UniProt: P0C0L4