FNIP2 antibody (C-Term)

Catalog No. ABIN499853

The Rabbit Polyclonal anti-FNIP2 antibody is suitable to detect FNIP2 in samples from Human, Mouse and Rat. It has been validated for WB and EIA.

Quick Overview for FNIP2 antibody (C-Term) (ABIN499853)

Target: FNIP2 (Folliculin Interacting Protein 2 (FNIP2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FNIP2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-FNIP2 Antibody

Binding Specificity: C-Term

Specificity: This antibody reacts to FNIP2.

Purification: Affinity chromatography purified via peptide column

Immunogen: FNIP2 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human FNIP2.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for FNIP2

Target: FNIP2 (Folliculin Interacting Protein 2 (FNIP2))

Alternative Name: FNIP2

Background: FNIP2 is the second protein found to interact with folliculin, the product of the Birt-Hogg-Dube (BHD) gene. Folliculin is thought to act as a tumor suppressor as mutations or loss of heterozygosity in this gene are associated with BHD syndrome-related renal tumors. Folliculin and FNIP1, a protein that shares 49 % identity to FNIP2, bind to AMPK, an important energy sensor in cells that negatively regulates the mammalian target of rapamycin (mTOR), a protein that is thought to be the master switch for cell growth and proliferation. FNIP1 and FNIP2 are able to form homo- and heteromeric multimers, suggesting these proteins may have a functional relationship. Multiple isoforms of FNIP2 are known to exist. This antibody is predicted to not cross-react with FNIP1.Synonyms: FNIP1-like protein, FNIPL, Folliculin-interacting protein 2, KIAA1450, MAPO1, O6-methylguanine-induced apoptosis 1 protein

Gene ID: 57600

NCBI Accession: NP_065891

UniProt: Q9P278