BLOC1S4 antibody (AbBy Fluor® 680)

Catalog No. ABIN4999007

This anti-BLOC1S4 antibody is a Rabbit Polyclonal antibody detecting BLOC1S4 in WB and IF (p). Suitable for Human, Mouse and Rat.

Quick Overview for BLOC1S4 antibody (AbBy Fluor® 680) (ABIN4999007)

Target: BLOC1S4 (CNO) (Cappuccino Homolog (CNO))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BLOC1S4 antibody is conjugated to AbBy Fluor® 680

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-BLOC1S4 Antibody (AbBy Fluor® 680)

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CNO/Cappuccino

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for BLOC1S4

Target: BLOC1S4 (CNO) (Cappuccino Homolog (CNO))

Alternative Name: Cappuccino

Background:

Synonyms: Cappuccino, Cappuccino homolog, Cappuccino homolog, FLJ11230, Protein cappuccino, Protein cappuccino homolog, BL1S4_HUMAN, Biogenesis of lysosome-related organelles complex 1 subunit 4, BLOC-1 subunit 4, BLOC1S4, BCAS4L, CNO.

Background: Biogenesis of lysosome-related organelles complex-1 (BLOC-1) is a multisubunit protein necessary for biogenesis of specialized organelles of the endosomal-lysosomal system (such as melanosomes and platelet-dense granules). The complex consists of coiled-coil-forming proteins Snapin, Pallidin, Cappuccino, Muted, BLOS1, BLOS2, and BLOS3. The localization of these proteins varies as they can be cytoplasmic, peripheral membrane bound or anchored to the vesicular membrane.Cappuccino, a primarily cytoplasmic protein, plays a role in the development of melanosomes, platelet-dense granules and other lysosome-related organelles. It interacts primarily with pallidin and Muted and has been implicated as an actin-nucleation factor that may play a role in crosstalk between microfilaments and microtubules.