TNNC1 antibody (pThr143) (AbBy Fluor® 680)

Catalog No. ABIN4999042

The Rabbit Polyclonal anti-TNNC1 antibody has been validated for IF (p). It is suitable to detect TNNC1 in samples from Human, Mouse and Rat.

Quick Overview for TNNC1 antibody (pThr143) (AbBy Fluor® 680) (ABIN4999042)

Target: TNNC1 (Cardiac Troponin C (TNNC1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNNC1 antibody is conjugated to AbBy Fluor® 680

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-TNNC1 Antibody (AbBy Fluor® 680)

Binding Specificity: pThr143

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human cardiac around the phosphorylation site of Troponin I Thr143

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for TNNC1

Target: TNNC1 (Cardiac Troponin C (TNNC1))

Alternative Name: cardiac Troponin I

Background:

Synonyms: cardiac Troponin I phospho Thr143, p-cardiac Troponin I Thr143, cardiac Troponin I phospho T143, p-cardiac Troponin I T143, Cardiac troponin I, Cardiomyopathy, familial hypertrophic, 7, included, CMD1FF, CMD2A, CMH7, cTnI, Familial hypertrophic cardiomyopathy 7, MGC116817, RCM1, p-Tn1, p-Tni, TNN I3, p-TNNC 1, p-TNNC1, p-TNNI3, p-Troponin I cardiac, Troponin I cardiac muscle, Troponin I cardiac muscle isoform, Troponin I type 3 cardiac, troponin I, cardiac 3, TroponinI, TNNI3_HUMAN.

Background: Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit, blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq].

Gene ID: 7137