CCDC18 antibody (AA 55-160) (AbBy Fluor® 680)

Catalog No. ABIN4999232

This anti-CCDC18 antibody is a Rabbit Polyclonal antibody detecting CCDC18 in IF (cc) and IF (p). Suitable for Human.

Quick Overview for CCDC18 antibody (AA 55-160) (AbBy Fluor® 680) (ABIN4999232)

Target: CCDC18 (Coiled-Coil Domain Containing 18 (CCDC18))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCDC18 antibody is conjugated to AbBy Fluor® 680

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-CCDC18 Antibody (AbBy Fluor® 680)

Binding Specificity: AA 55-160

Predicted Reactivity: Human,Mouse,Rat,Dog,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CCDC18

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CCDC18

Target: CCDC18 (Coiled-Coil Domain Containing 18 (CCDC18))

Alternative Name: CCDC18

Background:

Synonyms: CCD18_HUMAN, Ccdc18, Coiled-coil domain-containing protein 18, Sarcoma antigen NY-SAR-24.

Background: CCDC18, also known as NY-SAR-41 or dJ717I23.1, is a 1,454 amino acid protein expressed as two isoforms and encoded by a gene mapping to human chromosome 1. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8 % of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.

Gene ID: 343099