GRIK3 antibody (N-Term)

Catalog No. ABIN499926

This anti-GRIK3 antibody is a Rabbit Polyclonal antibody detecting GRIK3 in WB and EIA. Suitable for Human, Mouse and Rat.

Quick Overview for GRIK3 antibody (N-Term) (ABIN499926)

Target: GRIK3 (Glutamate Receptor, Ionotropic, Kainate 3 (GRIK3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRIK3 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-GRIK3 Antibody

Binding Specificity: N-Term

Purification: Affinity chromatography purified via peptide column

Immunogen: Grik3 antibody was raised against a 13 amino acid peptide near the amino terminus of the Human Grik3.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for GRIK3

Target: GRIK3 (Glutamate Receptor, Ionotropic, Kainate 3 (GRIK3))

Alternative Name: GRIK3 / GLUR7

Background: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik3, also known as glutamate receptor 7, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik3 is highly homologous to the related ionotrophic glutamate receptors Grik2 and Grik1. Grik3 has recently been shown to be an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses as grik3-null mice show significantly reduced short- and long-term synaptic potentiation. Other reports have suggested that different polymorphisms in the Grik3 protein may be associated with neurological defects such as recurrent major depressive disorder and schizophrenia.Synonyms: EAA5, Excitatory amino acid receptor 5, GluR-7, Glutamate receptor 7, Glutamate receptor ionotropic kainate 3

Gene ID: 2899

UniProt: Q13003

Pathways: Synaptic Membrane