HINT1 antibody (Center)

Catalog No. ABIN499948

This Rabbit Polyclonal antibody specifically detects HINT1 in WB, IF and EIA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for HINT1 antibody (Center) (ABIN499948)

Target: HINT1 (Histidine Triad Nucleotide Binding Protein 1 (HINT1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HINT1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-HINT1 Antibody

Binding Specificity: Center

Specificity: This antibody reacts to HINT1.

Purification: Affinity chromatography purified via peptide column

Immunogen: HINT1 antibody was raised against a 17 amino acid peptide near the center of the human HINT1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 1 - 2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for HINT1

Target: HINT1 (Histidine Triad Nucleotide Binding Protein 1 (HINT1))

Alternative Name: HINT1

Background: Histidine triad nucleotide-binding protein 1 (HINT1) is a member of the histidine triad (HIT) protein family, a group of small nucleotide-binding and -hydrolyzing proteins. HINT1 interacts with several diverse proteins and has been suggested to have tumor suppressive activities. HINT1 catalyzes the hydrolysis of adenosine 5'-monophoramidate substrates such as AMP-morpholidate, but its enzymatic function does not appear to play a role in its tumor suppression. Recent experiments demonstrate that HINT1 forms a complex with POSH and JNK in vivo, inhibiting AP-1 activity and the phosphorylation of c-Jun, and this action could contribute to the tumor suppressor activity of HINT1. Other studies raise the possibility of HINT1 as a candidate gene for schizophrenia.Synonyms: Adenosine 5'-monophosphoramidase, HINT, HINT1, Histidine triad nucleotide-binding protein 1, PKCI-1, PKCI1, PRKCNH1, Protein kinase C inhibitor 1, Protein kinase C-interacting protein 1

Gene ID: 3094

NCBI Accession: NP_005331

UniProt: P49773