IER3 antibody (Center)

Catalog No. ABIN499960

This Rabbit Polyclonal antibody specifically detects IER3 in WB, IHC (p) and EIA. It exhibits reactivity toward Human and Mouse.

Quick Overview for IER3 antibody (Center) (ABIN499960)

Target: IER3 (Immediate Early Response 3 (IER3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IER3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-IER3 Antibody

Binding Specificity: Center

Specificity: This antibody reacts to IEX1.

Purification: Affinity chromatography purified via peptide column

Immunogen: IEX1 antibody was raised against a 24 amino acid peptide near the center of human IEX1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 2 - 4 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for IER3

Target: IER3 (Immediate Early Response 3 (IER3))

Alternative Name: IER3 / IEX1

Background: IEX-1 is a stress inducible gene that is induced by ionizing radiation, ultraviolet radiation, and a variety of growth factors, i.e., FAS and TNF-a. IEX-1 is widely expressed in epithelial and endocrine tissues, as well as in vascular endothelium. It plays an important role in the regulation of cellular growth, cell death and oncogenesis. IEX-1 is precisely regulated by multiple transcription factors such as p53, NF-kappaB/rel, Sp1 and c-Myc, to ensure rapid and transient expression of IEX-1 in cells under a variety of stress conditions. IEX-1 is expressed as both a longer form (IEX1L) and a splice variant, designated IEX1S. It is localized to the nucleus and perinuclear region. Overexpression of IEX-1 facilitates apoptosis and cell cycle progression, whereas disruption of IEX-1 expression is associated with decreases in both apoptosis and cell cycle progression.Synonyms: DIF2, Differentiation-dependent gene 2 protein, GLY96, IEX-1, Immediate early protein GLY96, Immediate early response 3 protein, PACAP-responsive gene 1 protein, PRG1, Radiation-inducible immediate-early gene IEX-1

Gene ID: 8870

UniProt: P46695

Pathways: Regulation of Carbohydrate Metabolic Process