FBXO43 antibody (C-Term)

Catalog No. ABIN499982

The Rabbit Polyclonal anti-FBXO43 antibody has been validated for WB and EIA. It is suitable to detect FBXO43 in samples from Human.

Quick Overview for FBXO43 antibody (C-Term) (ABIN499982)

Target: FBXO43 (F-Box Protein 43 (FBXO43))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXO43 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-FBXO43 Antibody

Binding Specificity: C-Term

Specificity: IL-1RAcP antibody was raised against a peptide corresponding to amino acids 525 to 540 of human IL-1RAcP, which is identical to those of mouse and rat origins. This polyclonal antibody has no cross activity to other members in the IL-1 receptor family.

Purification: Affinity chromatography purified via peptide column

Immunogen: Human IL-1RAcP (C-Terminus 2) Peptide

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 1/1000 to 1/2000 dilution. An approximately 66 kDa band can be detected.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for FBXO43

Target: FBXO43 (F-Box Protein 43 (FBXO43))

Alternative Name: FBXO43

Background: The pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP) (1). IL-1RAcP forms a complex with IL-1RI in response to IL-1 treatment. The IL-1 receptor-associated kinase (IRAK), which mediates activation of NFkappa-B inducing kinae (NIK) and of NF-kappaB, recruits to the IL-1R complex through IL-1RAcP (2). IL-1 activation of stress-activated protein kinase and of acid sphingomyelinase also requires IL-1RAcP (3,4). Like IL-1RI, IL-1RAcP subunit is essential for IL-1 mediated cellular response. IL-1RAcP is expressed in many tissues.Synonyms: EMI2, Endogenous meiotic inhibitor 2, F-box only protein 43, FBP5B

Gene ID: 100101275

UniProt: Q8AXF4