FBXO43 antibody (C-Term)

Catalog No. ABIN499984

This Rabbit Polyclonal antibody specifically detects FBXO43 in WB, IF and EIA. It exhibits reactivity toward Human.

Quick Overview for FBXO43 antibody (C-Term) (ABIN499984)

Target: FBXO43 (F-Box Protein 43 (FBXO43))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXO43 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-FBXO43 Antibody

Binding Specificity: C-Term

Specificity: IL-1RAcP antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of IL-1RAcP, which differs from the sequence of mouse origin by three amino acids. It has no cross activity to other member in the IL-1 receptor family.

Purification: Affinity chromatography purified via peptide column

Immunogen: Human IL-1RAcP (C-Terminus) Peptide

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 1/500 to 1/1000. An approximately 66 kDa band can be detected.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for FBXO43

Target: FBXO43 (F-Box Protein 43 (FBXO43))

Alternative Name: FBXO43

Background: The pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1 receptor I(IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP) (1).IL-1 RAcP forms a complex with IL-1RI in response to IL-1 treatment. The IL-1 receptor-associated kinase (IRAK), which mediates activation of NF-kappaB inducing kinae (NIK) and of NF-kappaB, recruites to the IL-1R complex through IL-1 RAcP(2). IL-1 activation of stress-activated protein kinase and of acid sphingomyelinase also requires IL-1RAcP(3,4). Like IL-1RI, IL-1RAcP subunit is essential for IL-1 mediated cellular response. IL-1RAcP is expressed in many tissues.Synonyms: EMI2, Endogenous meiotic inhibitor 2, F-box only protein 43, FBP5B

Gene ID: 100101275

UniProt: Q8AXF4