NKIRAS1 antibody (Center)
Quick Overview for NKIRAS1 antibody (Center) (ABIN500110)
Target
See all NKIRAS1 AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- Center
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Specificity
- This antibody detects both kappaB-ras1 and kappaB-ras2.
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Cross-Reactivity (Details)
- Species reactivity (tested):Human, mouse, rat
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Purification
- Peptide afinity chromatography
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Immunogen
- KappaB ras antibody was raised against a 18 amino acid peptide from near the center of human KappaB ras 1.
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Isotype
- IgG
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Application Notes
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ELISA. Western blot: 2 - 4 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
Restrictions
- For Research Use only
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Buffer
- PBS containing 0.02 % sodium azide
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Preservative
- Sodium azide
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Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handling Advice
- Avoid repeated freezing and thawing.
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Storage
- 4 °C/-20 °C
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Storage Comment
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- NKIRAS1 (NFKB Inhibitor Interacting Ras-Like 1 (NKIRAS1))
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Alternative Name
- NKIRAS1
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Background
- KappaB ras-1 (kappaB-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with IkappaB (IkappaB), an inhibitor of the transcription factor NF-kappaB. IkappaB exists in two homologous forms, IkappaB-alpha and IkappaB-beta, although IkappaB-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive IkappaB-alpha-NF-kappaB complexes can shuttle in and out of the nucleus, IkappaB-beta-NF-kappaB complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the IkappaB-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of IkappaB-beta and regulating the rate of degradation of IkappaB-beta.Synonyms: KBRAS1, NF-kappa-B inhibitor-interacting Ras-like protein 1
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Gene ID
- 28512
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UniProt
- Q9NYS0
Target
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