DKK3 antibody (AA 31-130) (AbBy Fluor® 750)

Catalog No. ABIN5001291

This Rabbit Polyclonal antibody specifically detects DKK3 in WB, IF (cc) and IF (p). It exhibits reactivity toward Mouse and Rabbit.

Quick Overview for DKK3 antibody (AA 31-130) (AbBy Fluor® 750) (ABIN5001291)

Target: DKK3

Reactivity: Mouse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DKK3 antibody is conjugated to AbBy Fluor® 750

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-DKK3 Antibody (AbBy Fluor® 750)

Binding Specificity: AA 31-130

Cross-Reactivity: Mouse, Rabbit

Predicted Reactivity: Human,Rat,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DKK3

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for DKK3

Target: DKK3

Background:

Synonyms: RIG, REIC, Dickkopf-related protein 3, Dickkopf-3, Dkk-3, hDkk-3, DKK3, UNQ258/PRO295

Background: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

Gene ID: 27122

UniProt: Q9UBP4