Ephrin A1 antibody (AA 101-205) (AbBy Fluor® 750)

Catalog No. ABIN5002037

This anti-Ephrin A1 antibody is a Rabbit Polyclonal antibody detecting Ephrin A1 in IF (cc) and IF (p). Suitable for Human.

Quick Overview for Ephrin A1 antibody (AA 101-205) (AbBy Fluor® 750) (ABIN5002037)

Target: Ephrin A1 (EFNA1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ephrin A1 antibody is conjugated to AbBy Fluor® 750

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Ephrin A1 Antibody (AbBy Fluor® 750)

Binding Specificity: AA 101-205

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Ephrin A1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Ephrin A1

Target: Ephrin A1 (EFNA1)

Alternative Name: Ephrin A1

Background:

Synonyms: Ephrin-A1, EFNA1, EPH-related receptor tyrosine kinase ligand 1, LERK-1, Immediate early response protein B61, Tumor necrosis factor alpha-induced protein 4, EPLG1, LERK1, TNFAIP4

Background: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.

Gene ID: 1942

UniProt: P20827

Pathways: RTK Signaling