Factor Viiia Light Chain (Light Chain) antibody (AbBy Fluor® 680)

Catalog No. ABIN5002290

This Rabbit Polyclonal antibody specifically detects Factor Viiia Light Chain in WB. It exhibits reactivity toward Human.

Quick Overview for Factor Viiia Light Chain (Light Chain) antibody (AbBy Fluor® 680) (ABIN5002290)

Target: Factor Viiia Light Chain

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: AbBy Fluor® 680

Application: Western Blotting (WB)

Product Details

Binding Specificity: Light Chain

Cross-Reactivity: Human, Mouse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Factor VIIIa light chain

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: Factor Viiia Light Chain

Background:

Synonyms: coagulation factor VIII, Ahf, Antihemophilic factor, Coagulation factor VIII, Coagulation factor VIII associated protein b, Coagulation factor VIII isoform b, Coagulation factor VIII procoagulent component, Coagulation factor VIIIc, Dna segment on chromosome x unique 1253 expressed sequence, Dxs1253e, F8, F8 protein, F8b, F8c, FactorVIII, FVIII, Hema, Hema coagulation factor VIIIc procoagulent component, Hemophilia a, Hemophilia classic, OTTHUMP00000061446, Procoagulant component, AHF, DXS1253E, F8B, F8C, FVIII, HEMA, FA8_HUMAN.

Background: This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation, factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008].