FMO3 antibody (AA 111-210) (AbBy Fluor® 750)

Catalog No. ABIN5002771

The Rabbit Polyclonal anti-FMO3 antibody has been validated for WB, IF (cc) and IF (p). It is suitable to detect FMO3 in samples from Human.

Quick Overview for FMO3 antibody (AA 111-210) (AbBy Fluor® 750) (ABIN5002771)

Target: FMO3 (Flavin Containing Monooxygenase 3 (FMO3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FMO3 antibody is conjugated to AbBy Fluor® 750

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-FMO3 Antibody (AbBy Fluor® 750)

Binding Specificity: AA 111-210

Predicted Reactivity: Human,Mouse,Rat,Cow,Monkey

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FMO3

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for FMO3

Target: FMO3 (Flavin Containing Monooxygenase 3 (FMO3))

Alternative Name: FMO3

Background:

Synonyms: Dimethylaniline monooxygenase [N oxide forming] 3, Dimethylaniline monooxygenase [N-oxide-forming] 3, Dimethylaniline monooxygenase 3, Dimethylaniline oxidase 3, dJ127D3.1, Flavin containing monooxygenase 3, FMO 3, FMO form 2, FMO II, FMO3, FMO3_HUMAN, FMOII, Hepatic flavin containing monooxygenase 3, Hepatic flavin-containing monooxygenase 3, MGC34400, TMAU, Trimethylamine monooxygenase.

Background: The Flavin containing monooxygenase family consists of five gene products, FMO1-5, that are major enzymatic oxidants involved in the metabolism of various therapeutics. Located in the liver, FMO3 is a hepatic microsomal enzyme that oxygenates soft nucleophiles such as secondary and tertiary amines. Through its N-oxygenase capabilities, FMO3 acts on a variety of xenobiotics to catalyze oxidative digestion. Defects in the FMO3 gene are the primary cause of trimethylaminuria (TMAuria), an inborn error of metabolism associated with a fishy body odor emitting from sweat, urine and breath. Genetic mutations in FMO3 lead to the N-oxidation of amino-trimethylamine derived from food products, thus producing the malodor associated with TMAuria.

Gene ID: 2328