KCNT2 antibody (AA 51-150) (AbBy Fluor® 750)

Catalog No. ABIN5005814

The AbBy Fluor® 750-conjugated Rabbit Polyclonal anti-KCNT2 antibody (ABIN5005814) specifically detects KCNT2 in IF (cc) and IF (p). The antibody is reactive with Human samples.

Quick Overview for KCNT2 antibody (AA 51-150) (AbBy Fluor® 750) (ABIN5005814)

Target: KCNT2 (Potassium Channel, Subfamily T, Member 2 (KCNT2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNT2 antibody is conjugated to AbBy Fluor® 750

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-KCNT2 Antibody (AbBy Fluor® 750)

Binding Specificity: AA 51-150

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human KCNT2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for KCNT2

Target: KCNT2 (Potassium Channel, Subfamily T, Member 2 (KCNT2))

Alternative Name: KCNT2

Background:

Synonyms: KCa4.2, Potassium channel, subfamily T, member 2, Sequence like an intermediate conductance potassium channel subunit, SLICK, SLO2.1, Sodium and chloride activated ATP sensitive potassium channel, Sodium and chloride activated ATP sensitive potassium channel Slo2.1, KCNT2_HUMAN.

Background: Voltage-gated K+ channels in the plasma membrane are important regulators of electrical signaling, controlling the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. KCNT2 is a 1,135 amino acid multi-pass transmembrane protein belonging to the potassium channel family (calcium-activated subfamily) of proteins. KCNT2 produces rapidly activating outward rectifier potassium currents in reponse to high intracellular sodium and chloride levels. Its channel activity is inhibited by ATP, inhalation anesthetics, such as isoflourane, and upon stimulation of G-protein coupled receptors, such as mAChR M1 and GluR-1. There are four isoforms of KCNT2 that are produced as a result of alternative splicing events.