KIR5.1 antibody (pSer416) (AbBy Fluor® 680)

Catalog No. ABIN5005872

This Rabbit Polyclonal antibody specifically detects KIR5.1 in IF (cc) and IF (p). It exhibits reactivity toward Human.

Quick Overview for KIR5.1 antibody (pSer416) (AbBy Fluor® 680) (ABIN5005872)

Target: KIR5.1 (KCNJ16) (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 16 (KCNJ16))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIR5.1 antibody is conjugated to AbBy Fluor® 680

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-KIR5.1 Antibody (AbBy Fluor® 680)

Binding Specificity: pSer416

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human KIR5.1 around the phosphorylation site of Ser416

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for KIR5.1

Target: KIR5.1 (KCNJ16) (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 16 (KCNJ16))

Alternative Name: KIR5.1

Background:

Synonyms: p-KIR5.1 phospho S416, 6430410F18Rik, AI132396, BIR9, Inward rectier K channel Kir5.1, Inward rectier K+ channel Kir5.1, Inward rectier potassium channel 16, IRK16, IRKG, KCNJ16, MGC33717, Potassium channel inwardly rectying subfamily J member 16, Potassium inwardly rectying channel subfamily J member 16, RP23-218O16.1, IRK16_HUMAN.

Background: The KIR family of potassium channels possess a greater tendency to allow potassium to flow into the cell rather than out of it. Kir4.1, also known as Kir1.2, is highly expressed in brain including glial cells, astrocytes and cortical neurons. Kir4.1 is also expressed in myelin-synthesizing oligodendrocytes and is crucial to myelination in the developing nervous system. The gene encoding human Kir4.1 maps to chromosome 1. Kir4.2, also known as Kir1.3, is expressed in kidney, lung, heart, thymus and thyroid during development. The gene encoding human Kir4.2 maps to chromosome 21 in the Down syndrome chromosome region 1, and Kir4.2 may play a role in the pathogenesis of Down?s syndrome. Kir 5.1 forms functional channels only by coexpression with either Kir4.1 or Kir4.2 in the kidney and pancreas. The gene encoding human Kir5.1 maps to chromosome 17.